P. M. Kekenes-Huskey

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

The paper investigates the stoichiometry and structure of the NKA-PLM regulatory complex using fluorescence lifetime assays and simulations, revealing a (alpha-beta-PLM)2 composition.

This study uses computational modeling to show that purinoreceptors and ectonucleotidases regulate ATP-induced calcium waveforms and microglia responses, with different waveforms driving distinct functional outcomes.

This study investigates how plant-derived calmodulin variants differentially regulate calcineurin through non-canonical interactions beyond calcium binding and canonical CaMBR binding.

This study uses molecular dynamics simulations to show that calmodulin's linker flexibility affects its binding kinetics to targets, with a labile linker reducing the ability to achieve the fully-bound state.

This study uses reaction-diffusion simulations to show that confinement and charge effects in narrow extracellular spaces influence the kinetics of coupled nucleotidase reactions.

The paper introduces MatchedMyo, a matched-filter algorithm to classify T-system structures in cardiac tissues, revealing heterogeneous T-system remodeling in disease models.

This study uses computational modeling to investigate how electrostatic interactions and conformational dynamics influence the binding of calcineurin’s disordered domain to calmodulin.