A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
M. J. Ruggiero, S. Malhotra, A. W. Fenton, L. Swint-Kruse, J. Karanicolas, B. Hagenbuch
The paper identifies a rheostat position in NTCP where substitutions produce varied functional effects, showing substrate-dependent transport changes and structural stability variations.
bioRxiv · Jul 2, 2020Biochemistry