S. Malhotra

Mapping the Arabidopsis thaliana proteome in PeptideAtlas and the nature of the unobserved (dark) proteome; strategies towards a complete proteome

This paper updates the Arabidopsis thaliana PeptideAtlas proteomics resource, identifies 78.6% of the predicted proteome, and uses a machine learning model to predict the dark proteome.

The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice

This paper investigates the pharmacokinetics and pharmacodynamics of 4-MU and its metabolite 4-MUG in mice, showing significant differences in exposure and bioavailability between administration routes.

A Low-Cost, 3D-Printed Biosensor for Rapid Detection of Escherichia coli

This paper presents a low-cost, 3D-printed biosensor for rapid detection of specific E. coli strains with high sensitivity and potential for point-of-care use.

Identification of bacteria strains using the Recombinase Polymerase Amplification assay on a miniaturized solid-state pH sensor

This paper develops a miniaturized solid-state pH sensor using RPA to rapidly and sensitively detect bacterial strains with high accuracy.

The pathobiology of Mycobacterium abscessus revealed through phenogenomic analysis

This study uses phenogenomic analysis to uncover virulence mechanisms and drug resistance in Mycobacterium abscessus by integrating phenotyping, genomics, and computational modeling.

The pore conformation of lymphocyte perforin

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.

A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

The paper identifies a rheostat position in NTCP where substitutions produce varied functional effects, showing substrate-dependent transport changes and structural stability variations.

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.