Author

B. Höcker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Assay:protein structure· 4 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein sequence· 1

Frequent Co-Authors

S. Romero-Romero· 3 shared S. Shanmugaratnam· 2 shared A. A. Jalan· 1 shared A. Rodriguez-Romero· 1 shared C. Tapia· 1 shared D. A. Fernandez-Velasco· 1 shared D. Baker· 1 shared D.-A. Silva· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

S. Romero-Romero

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hydrophobic Clusters Direct Folding of a Synthetic Chimeric Protein

A. A. Jalan, L. Hassine, S. Romero-Romero, J. Hübner, K. Schweimer, B. Höcker

This study investigates how hydrophobic clusters influence the folding and stability of a synthetic chimeric protein made from fragments of two different proteins.

bioRxiv · Sep 29, 2023 · PreprintBiophysics

Retracing the evolution of a modern periplasmic binding protein

F. Michel, S. Romero-Romero, B. Höcker

This study reconstructs a single-lobed progenitor of a periplasmic binding protein by deconstructing a modern RBP, showing that recombination of its lobes restores function and structure.

bioRxiv · May 30, 2023Biochemistry

Extension of a de novo TIM barrel with a rationally designed secondary structure element

J. G. Wiese, S. Shanmugaratnam, B. Höcker

The paper extends a de novo TIM barrel with a rationally designed helix, validates the design with experimental data, and demonstrates its potential for future enzyme design.

bioRxiv · Oct 16, 2020Biochemistry

The stability landscape of de novo TIM barrels explored by a modular design approach

S. Romero-Romero, M. Costas, D.-A. Silva, S. Kordes, E. Rojas-Ortega, Y. Guerra, C. Tapia, S. Shanmugaratnam, A. Rodriguez-Romero, D. Baker, B. Höcker, D. A. Fernandez-Velasco

This study designs a family of stable de novo TIM barrels with diverse thermodynamic properties and identifies epistatic effects influencing their stability.

bioRxiv · Sep 29, 2020Biochemistry