Intact nucleosomal context enables chromodomain reader MRG15 to distinguish H3K36me3 from -me2
S. Faulkner, A. M. Couturier, B. Josephson, T. Watts, B. G. Davis, F. Esashi
The paper shows MRG15 distinguishes H3K36me3 from H3K36me2 in intact nucleosomes, revealing a methyl-switch mechanism dependent on DNA backbone interactions.
bioRxiv · Apr 30, 2020 · PreprintBiochemistry