A Novel Transcription Factor Combination for Direct Reprogramming to a Spontaneously Contracting Human Cardiomyocyte-like State
M. R. Tejeda, H. Fonoudi, C. J. Weddle, J.-M. DeKeyser, B. Lenny, A. K. Fetterman, T. Magdy, Y. Sapkota, C. Epting, P. W. Burridge
This paper identifies a transcription factor combination (MST) that successfully reprograms human fibroblasts into cardiomyocyte-like cells with spontaneous contraction and gene expression profiles similar to cardiomyocytes.
bioRxiv · Mar 14, 2023Cell Biology