In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli
This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.
bioRxiv · Jun 2, 2020Microbiology