Author

M. Nekorchuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

J. D. Estes· 3 shared K. Busman-Sahay· 3 shared M. Aid· 2 shared A. B. Ventura· 1 shared A. Bhusari· 1 shared A. Colarusse· 1 shared A. Kaur· 1 shared A. Martinot· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

J. D. Estes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ad26.COV2.S Prevents SARS-CoV-2 Induced Pathways of Inflammation and Thrombosis in Hamsters

M. Aid, S. Vidal, C. Piedra-Mora, S. Ducat, C. Chan, S. Bondoc, A. Colarusse, C. Starke, M. Nekorchuk, K. Busman-Sahay, J. Estes, A. Martinot, D. H. Barouch

This study shows that Ad26.COV2.S vaccine prevents SARS-CoV-2-induced inflammation and thrombosis in hamsters by reducing proinflammatory and prothrombotic pathways and restoring gene expression profiles to uninfected levels.

bioRxiv · Sep 30, 2021 · PreprintMicrobiology

Virus-Dependent Immune Conditioning of Tissue Microenvironments

S. Jiang, C. N. Chan, X. Rovira-Clave, H. Chen, Y. Bai, B. Zhu, E. McCaffrey, N. F. Greenwald, C. Liu, G. L. Barlow, J. L. Weirather, K. Busman-Sahay, M. Nekorchuk, M. Terry, S. Younger, , G. P. Nolan

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

bioRxiv · May 21, 2021Immunology

IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

S. Pereira Ribeiro, M. Aid, F. P. Dupuy, C. Ngai Chan, J. Hultquist, C. Deleage, E. Moysi, D. A. Kulpa, L. Li, X. Xu, B. Tamilselvan, J. A. Tomalka, M. Nekorchuk, K. Busman-Sahay, R. Bordi, , R.-P. Sekaly

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

bioRxiv · Feb 26, 2021 · PreprintImmunology

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

bioRxiv · Jun 2, 2020Microbiology