SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
K. A. Tran, M. Gilbert, B. N. Vazquez, A. Ianni, B. Garcia, A. Vaquero, S. Berger
This study identifies NUCKS1 as a novel SIRT7 interactor that promotes chromatin binding during senescence and liver aging, leading to metabolic and inflammatory gene expression.
bioRxiv · Feb 5, 2024Cell Biology