Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment
N. P. Skillin, B. E. Kirkpatrick, K. M. Herbert, B. R. Nelson, G. K. Hach, K. A. Gunay, R. M. Khan, F. W. DelRio, T. J. White, K. S. Anseth
This study shows that substrate stiffness anisotropy guides myotube alignment through collective cellular dynamics in C2C12 myoblasts.
bioRxiv · Aug 8, 2023Bioengineering