Predicting the Disposition of the Antimalarial Drug Artesunate and its Active Metabolite Dihydroartemisinin Using Physiologically-Based Pharmacokinetic Modeling
This study develops a whole-body PBPK model to predict the tissue-specific pharmacokinetics of artesunate and dihydroartemisinin in rats and humans, showing good agreement with validation data.
bioRxiv · Oct 28, 2020Pharmacology & Toxicology