Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin
A. Naschberger, P. Juyoux, J. von Velsen, B. Rupp, M. Bowler
This paper shows that controlled dehydration of afamin crystals stabilizes a new orthorhombic form, revealing conformational flexibility and Gadoteridol binding sites, while highlighting issues with using single crystal structures for modeling.
bioRxiv · Jun 18, 2019Biochemistry