Hierarchical coupling between ATP hydrolysis and Hsp90's client binding site
S. Wolf, B. Sohmen, B. Hellenkamp, J. Thurn, G. Stock, T. Hugel
The paper identifies a hierarchical mechanism by which ATP hydrolysis in Hsp90 influences its substrate binding site through structural asymmetry and allosteric dynamics.
bioRxiv · Feb 15, 2020Biophysics