An Association Test of the Spatial Distribution of Rare Missense Variants within Protein Structures Improves Statistical Power of Sequencing Studies
Bowen Jin, John A. Capra, Penelope H. Benchek, Nicholas R. Wheeler, Adam Christian Naj, Kara L. Hamilton‐Nelson, John J. Farrell, Yuk Yee Leung, Brian W. Kunkle, Badri Vadarajan, Gerard D. Schellenberg, Richard P Mayeux, Li‐San Wang, Lindsay A. Farrer, Margaret Ann Pericak‐Vance, , William S. Bush
POKEMON improves statistical power for detecting associations between rare missense variants and phenotypes by analyzing their spatial distribution on protein structures.
Genome Research · Apr 1, 2022Peer-reviewedBioinformatics