Toggling of NKG2A expression drives functional specialization of iPSC-derived CAR NK cells
Minoru Kanaya, Camille Philippon, Herman Netskar, Michelle Sætersmoen, Artur Cieślar‐Pobuda, Lamberto Torralba‐Raga, Giovanna Perinetti Casoni, Quirin Hammer, Marianna Vincenti, Merete Thune Wiiger, Silje Zandstra Krokeide, Hanna Julie Hoel, Eivind Heggernes Ask, Mizuha Kosugi‐Kanaya, Lise Kveberg, , Karl‐Johan Malmberg
This study shows that NKG2A expression in iPSC-derived NK cells drives functional specialization, enhancing cytotoxicity and IFN-γ production independent of HLA-E interactions.
bioRxiv · Aug 20, 2025 · PreprintImmunology