Dan S. Kaufman

Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells

This study identifies functional differences in term decidual natural killer cells compared to early gestation and develops a protocol to generate functional early gestation-like dNK from iPSC.

Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping

This study uses optical genome mapping to detect genomic rearrangements in gene-edited iPSCs, showing that transposons and lentiviral methods cause more insertions than CRISPR-Cas9.

Toggling of NKG2A expression drives functional specialization of iPSC-derived CAR NK cells

This study shows that NKG2A expression in iPSC-derived NK cells drives functional specialization, enhancing cytotoxicity and IFN-γ production independent of HLA-E interactions.

Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression

The paper identifies PUF60's role in cancer progression by combining CRISPR screens and RNA-omics, showing its splicing activity supports TNBC proliferation and is a potential therapeutic target.