Unlocking de novo antibody design with generative artificial intelligence
Amir Shanehsazzadeh, Matt McPartlon, George W. Kasun, Andrea K. Steiger, John M. Sutton, Edriss Yassine, Cailen M. McCloskey, Robel Gemechu Haile, Richard W. Shuai, Julian Alverio, Goran Rakočević, Simon Levine, Jovan Cejovic, Jahir M. Gutierrez, Alex Morehead, , Sharrol T. Bachas
Deep generative models combined with high-throughput screening design de novo anti-HER2 antibodies without further optimization, yielding nanomolar binders functionally comparable or superior to trastuzumab.
bioRxiv · Jan 8, 2023 · PreprintSynthetic Biology