Robel Gemechu Haile

Origin-1 generates high-confidence, specific antibodies against zero-prior epitopes through generative AI, validated with biophysical assays and cryo-EM.

Deep generative models combined with high-throughput screening design de novo anti-HER2 antibodies without further optimization, yielding nanomolar binders functionally comparable or superior to trastuzumab.

Language models trained on high-throughput affinity data predict KD of unseen antibody variants across three orders of magnitude, and a "naturalness" score can be optimised alongside affinity.