Deep reinforcement learning-driven discovery of a MsbA-targeted small-molecule antibiotic for the treatment of Acinetobacter baumannii infection
Lei Wang, Baixin Jing, Qingxin Liu, Jiale Zhong, Zunsheng Han, Yingying Yang, Hongwei Jin, Yanyan Li, Liang Peng, Song Wu, Jie Xia
This study uses AI-driven drug design to discover a new MsbA-targeted antibiotic, Y-11, effective against carbapenem-resistant Acinetobacter baumannii with reduced toxicity and resistance.
bioRxiv · Sep 15, 2026 · PreprintBiochemistry