OptoGranules reveal the evolution of stress granules to ALS-FTD pathology
Peipei Zhang, Baochang Fan, Peiguo Yang, Jamshid P. Temirov, James Messing, Hong Joo Kim, J. Paul Taylor
The paper introduces OptoGranules, a light-inducible system to control stress granule dynamics in cells, showing that persistent stress granule assembly leads to ALS-FTD-like pathology.
bioRxiv · Jun 18, 2018 · PreprintNeuroscience