Author

Barbara De Kegel

Broad InstitutePrimary ORCID profile (0000-0002-4194-234X · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Barbara De KegeliD4 papers · University College Dublin

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alex T. Kalinka· 1 shared Catarina D. CampbelliD· 1 shared Francisca VázqueziD· 1 shared Joshua M. DempsteriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Alex T. Kalinka

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1 paper

Recent·Most cited

Controlling False Discovery in CRISPR Screens

Joshua M. Dempster, Barbara De Kegel, Alex T. Kalinka, Francisca Vázquez, Catarina D. Campbell

This paper introduces Chronos, a module for estimating false discovery rates in CRISPR screens, showing it outperforms existing methods like MAGeCK in controlling false positives.

bioRxiv · Apr 24, 2025 · PreprintBioinformatics