Alex T. Kalinka

This paper introduces Chronos, a module for estimating false discovery rates in CRISPR screens, showing it outperforms existing methods like MAGeCK in controlling false positives.

The paper benchmarks CRISPR sgRNA design algorithms and creates smaller, efficient libraries for loss-of-function screens.

This study uses brain organoids to show that male sex hormones increase excitatory neuron production in the human neocortex by enhancing progenitor proliferation and affecting chromatin remodeling.

This paper improves sensitivity in differential expression analysis for under-powered RNA-seq experiments by learning a decision boundary to control FDR and combining it with elastic-net logistic regression.

The paper uses transcriptomics and imaging to study mRNA localization in Drosophila oogenesis, revealing widespread localization, dependence on microtubules, and differences between localized and unlocalized mRNAs.