Transcriptomic and pathological analysis of the hnRNP network reveals glial involvement in FTLD pathological subtypes
Ariana P. Gatt, Yazead Buhidma, Katherine Fodder, Jack Humphrey, Sandrine C. Foti, Barbara Frias, Bridget C. Benson, Priya Gami‐Patel, Lauren M. Gittings, Christina E. Toomey, Tammaryn Lashley
This study investigates the hnRNP network's role in FTLD-TDP subtypes using single-nuclei RNA-sequencing and immunohistochemistry, finding glial-specific RNA processing changes associated with different pathological subtypes.
bioRxiv · Jul 14, 2025 · PreprintNeuroscience