Lauren M. Gittings

This study uses multi-omic profiling of synaptosomes to identify molecular changes in C9-FTD, revealing disrupted synaptic pathways and localized cryptic transcripts.

This study shows ADAR2-mediated RNA editing promotes TDP-43 nuclear export and alters its RNA binding, contributing to neurodegenerative disease mechanisms.

This study investigates the hnRNP network's role in FTLD-TDP subtypes using single-nuclei RNA-sequencing and immunohistochemistry, finding glial-specific RNA processing changes associated with different pathological subtypes.

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.