Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment
Florian J. Raabe, Anna Hausruckinger, Miriam Gagliardi, Ruhel Ahmad, Valéria de Almeida, Sabrina Galinski, Anke Hoffmann, Liesa Weigert, Christine K. Rummel, Vanessa Murek, Lucia Trastulla, Laura Jimenez-Barron, Alessia Atella, Susanne Maidl, Danusa Menegaz, , Michael J. Ziller
This study identifies alternative polyadenylation (APA) as a molecular mechanism linking polygenic risk for schizophrenia to synaptic impairments through functional analysis in induced neurons.
bioRxiv · Jan 9, 2024 · PreprintNeuroscience