Imaging-based temporal dynamics of electrophile-induced NRF2 signaling in liver cells identifies adaptive versus adverse repeated exposure conditions.
Marije Niemeijer, Liesanne Wolters, Bas ter Braak, Hiral Patel, Dawn Yates, Raju Sharma, Beate Nicol, Chris Sparham, Sarah Hatherell, A. Middleton, Andrew White, Joost B. Beltman, Bob van de Water
This study uses live cell imaging to analyze NRF2 activation dynamics in response to repeated electrophile exposure, showing that recovery periods enable adaptive responses.
bioRxiv · Aug 22, 2025 · PreprintPharmacology & Toxicology