Systems BiologyNature ProtocolsPeer-reviewed
Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS
Jeanette Johnson, Ashley P. Tsang, Jacob T. Mitchell…·Genevieve Stein-O’Brien
The paper introduces computational tools for NMF analysis of single-cell RNA-seq data, demonstrating their use in quantifying cell state transitions in pancreatic cancer.