Author

Ashley P. Tsang

Johns Hopkins UniversityORCID 0000-0002-0174-6360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Anand Devaprasath D. JeyasekharaniD· 1 shared Arvind RaoiD· 1 shared Ben Kinny-Köster· 1 shared Brian J. LaneiD· 1 shared Char Loo TaniD· 1 shared Chartsiam TipgomutiD· 1 shared Claudio TripodoiD· 1 shared Colm KeaneiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

Anand Devaprasath D. JeyasekharanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma

Liang Hong, Subhashini Joshi, Min Liu, Shruti Sridhar, Maria Victoria Revuelta, Zi Yan Charmaine Ong, Norbert S. C. Tay, Wei Xian Clemence Lai, Chartsiam Tipgomut, Patrick William Jaynes, Yanfen Peng, Char Loo Tan, Susan Swee‐Shan Hue, Siok-Bian Ng, Sanjay De Mel, , Anand Devaprasath D. Jeyasekharan

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS

Jeanette Johnson, Ashley P. Tsang, Jacob T. Mitchell, David L. Zhou, Julia Bowden, Emily F. Davis-Marcisak, Thomas D. Sherman, Ted Liefeld, Melanie Loth, Loyal A. Goff, Jacquelyn W. Zimmerman, Ben Kinny-Köster, Elizabeth M. Jaffee, Pablo Tamayo, Jill P. Mesirov, , Genevieve Stein-O’Brien

The paper introduces computational tools for NMF analysis of single-cell RNA-seq data, demonstrating their use in quantifying cell state transitions in pancreatic cancer.

Nature Protocols · Nov 21, 2023Peer-reviewedSystems Biology