Discovering genetic interactions bridging pathways in genome-wide association studies
Gang Fang, Wen Wang, Vanja Paunić, Hamed Heydari, Michael Costanzo, Xiaoye Liu, Xiaotong Liu, Benjamin VanderSluis, Benjamin Oately, Michael S. Steinbach, Brian Van Ness, Eric E. Schadt, Nathan Pankratz, Charles M. Boone, Vipin Kumar, Chad L. Myers
This paper introduces BridGE, a method to detect pathway-level genetic interactions from GWAS data, revealing significant interactions in multiple diseases.
Nature Communications · Sep 19, 2019Peer-reviewedGenetics