Sonic Hedgehog Is An Important Regulator Of Intervertebral Disc Homeostasis And Rejuvenation
Sarthak Mohanty, Rajakumar Anbazhagan, Paul Pricop, Sarah Loh, Robert Pinelli, Tom Ross, Eric A. Bogner, James C Farmer, Russel C Huang, Darren R. Lebl, Bernard A. Rawlins, Han Jo Kim, Harvinder S. Sandhu, Matthew E. Cunningham, Sheeraz Qureshi, , Chitra Lekha Dahia
This study shows that Sonic Hedgehog signaling is crucial for maintaining intervertebral disc health and can be targeted to treat degeneration.
bioRxiv · Sep 22, 2026 · PreprintDevelopmental Biology