Methicillin-Resistant Staphylococcus aureus has Phenotypic Variation in mecA Expression that Alters Antibiotic Sensitivity
Dongzhu Ma, Rekha Arya, Beth A. Knapick, Nadine M. Sadaka, Jewelia Rempuszewski, Claudette Moul, Jonathan Brendan Mandell, Neel B. Shah, James B. Doub, Charles G. Gish, Dana M. Parker, Niosha Parvizi, Stefanie Arlene Sydlik, Hunter B. Wood, Alecia B. Rokes, , Kenneth L. Urish
This study shows that MRSA can exhibit antibiotic sensitivity due to reduced mecA expression and altered PBP2a levels in certain environments, suggesting new therapeutic targets.
Antimicrobial Agents and Chemotherapy · Feb 12, 2026Peer-reviewedMicrobiology