A microfluidic-based model of nociceptor sensitization reveals a direct activation of sensory axons by prostaglandin E2
Georgios Kimourtzis, Natasha Rangwani, Bethan J. Jenkins, Peter Anthony McNaughton, Ramin Raouf
The paper shows that PGE2 directly depolarizes nociceptive axons, causing sustained activation of pain-sensing neurons without noxious stimuli.
bioRxiv · Mar 18, 2022 · PreprintNeuroscience