Blunted fear-evoked striatal dopamine release in individuals with a family history of psychosis
Rami Hamati, Cecelia Shvetz, Bianca Chidiac, Hussein Bdair, Katie Dinelle, Daphne J. Holt, Clifford Cassidy, Lauri J. Tuominen
The paper investigates dopamine release during fear conditioning in individuals with and without a family history of psychosis, finding reduced dopamine release in relatives despite normal learning, supporting the chaotic dopamine hypothesis.
bioRxiv · Aug 27, 2026 · PreprintNeuroscience