DNA polymerase kappa stabilized by PTBP2 interacts with MRE11 and promotes genomic instability in leukemia cells
Shristi Lama, Bibhudev Barik, Sajitha IS, Tannistha Sarkar, Sayantan Chanda, Monalisa Behera, Payel Guha, Subhankar Priyadarshi Behera, Sutapa Biswas, Sonali Mohapatra, Ghanashyam Biswas, Soumen Chakraborty
The paper shows PTBP2 stabilizes Pol{kappa} mRNA, leading to genomic instability in CML cells by interacting with MRE11 and promoting DNA damage.
Cell Death Discovery · Feb 10, 2026Peer-reviewedCancer Biology