Intraductal Papillary Mucinous Neoplasm Cellular Plasticity is linked with Repeat Element Dysregulation
Amaya Pankaj, Michael J. Raabe, M. Lisa Zhang, Yuhui Song, Bidish K. Patel, Katherine Xu, Joshua R. Kocher, Evan Lang, Peter Richieri, Nicholas J. Caldwell, Peiyun Ni, Maria L Ganci, Linda T. Nieman, Vikram Deshpande, Nabeel M. Bardeesy, , Yasmin Genevieve Hernandez-Barco
This study uses spatial transcriptomics to show that IPMN subtypes form a molecular continuum originating from gastric-type cells, with repeat element expression linked to disease progression.
bioRxiv · Jan 14, 2025 · PreprintCancer Biology