Alcohol-Induced Increase in the Content of CYP2E1 in Human Liver Microsomes Causes a Multifold Activation of CYP3A4 and Attenuates its Cooperativity
Bikash Dangi, Nadezhda Y Davydova, Nikita E Vavilov, Victor G Zgoda, Dmitri R Davydov
This study shows that increased CYP2E1 in liver microsomes from heavy drinkers enhances CYP3A4 activity and reduces its cooperativity, suggesting alcohol's impact on drug metabolism.
bioRxiv · Mar 9, 2020Biochemistry