ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines
Shu-Xia Cao, Ying Zhang, Xingyue Hu, Bin Hong, Peng Sun, Hai-Yang He, Hong-Yan Geng, Ai‐Min Bao, Shumin Duan, Jian‐Ming Yang, Tianming Gao, Hong Lian, Xiao‐Ming Li
This study shows that ErbB4 deletion in locus coeruleus noradrenergic neurons increases neuronal firing and catecholamines, leading to mania-like behaviors that are reversed by lithium or catecholaminergic receptor antagonists.
eLife · Sep 4, 2018Peer-reviewedNeuroscience