Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome
Lvqin Zheng, Bin Tsai, Ning Gao
This study reports cryo-EM structures of nucleosomes with deoxyinosine and their complexes with DNA glycosylase AAG, revealing how AAG accesses damaged sites on nucleosomes through structural dynamics.
Cell Discovery · Jun 20, 2023Peer-reviewedMolecular Biology