Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers
Shenglan Zhang, Yinghong Lin, Ting Gao, Binfen Chen, Weibin Wu, Shanshan Fang, Kexin Fan, Yuqing Lai, Yezi Lin, Rongqin Ke, Sanshu Li
This study develops a method to measure ligand-binding events in structured RNAs by integrating a hammerhead ribozyme with a multi-base pair bridge, demonstrating its effectiveness with riboswitch candidates.
Acta Biochimica et Biophysica Sinica · Jun 11, 2025Peer-reviewedMolecular Biology