Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Huihong Li, Zhiran Xie, Yuxuan Tian, Ruoyin Zhou, Yaxi Yang, Bingying Lin, Si Chen, Jie Wu, Zihan Deng, Jianwei Li, Mingjie Chen, Xueke Liu, Yushan Sun, Naili Wei, Bing Yuan Huang, Xiaoyu Ji
The paper identifies a conserved microglial synaptic pruning pathway linked to Alzheimer's disease and epilepsy through genome-wide transcriptomic analysis across multiple models and human cohorts.
Molecular Psychiatry · Oct 26, 2025Peer-reviewedNeuroscience