Machine Learning Guided Structure Activity Discovery of Polymer Configurations in Lipid Nanoparticles for Kiss-and-Run Endosomal Escape
Jiamin Wu, Xia Qin, Po-Yu Chou, Binh Tran, Isaiah O. Betinol, Alexandra Birkenshaw, Hussain Haider, Ethan Curtis, Natalie B. Jones, Jolene P. Reid, Colin J. Ross, Shyh‐Dar Li
This paper optimizes lipid nanoparticle polymer configurations for endosomal escape using machine learning, achieving high gene editing efficiency in mice.
bioRxiv · Aug 13, 2025 · PreprintBioengineering