Functional impact of PCSK9 variants on LDL uptake in a knockout hepatic model
Hongmei Li, Huili Liu, Wenxin Xu, Yuanjun Zeng, Pengfei Huang, Jiawang Guo, Binxiang Cai, Yajing Chen, Yanyan Lin, Chunbin Zhang
The paper assesses the functional impact of PCSK9 variants on LDL uptake using a knockout hepatic model, revealing heterogeneity in variant activities and providing insights into their mechanisms.
PLoS ONE · Oct 26, 2026Peer-reviewedBiochemistry