The piRNA Response to Retroviral Invasion of the Koala Genome
Tianxiong Yu, Birgit S. Koppetsch, Sara Pagliarani, Stephen Douglas Johnston, Noah J. Silverstein, Jeremy Luban, Keith Joseph Chappell, Zhiping Weng, William E. Theurkauf
The paper analyzes the piRNA response to retroviral invasion in koalas, finding that KoRV piRNAs are sense-biased and derived from unspliced transcripts, suggesting a conserved innate immune mechanism.
Cell · Jan 1, 2019Peer-reviewedGenetics