Tianxiong Yu

The paper identifies the NFYA-NURF axis as essential for maintaining accessible chromatin at poised meiotic promoters, which is required for meiotic entry in mice.

The paper constructs a single-nucleus multi-omic atlas of adult human tissues, identifying regulatory elements and variant effects across 21 tissues.

This study examines the evolutionary dynamics of pachytene piRNAs in mouse subspecies hybrids, showing that rapidly evolving piRNA genes can gain or lose mRNA targets in hybrids.

The paper identifies NFYA as a factor that promotes accessible chromatin at meiotic gene promoters in pre-meiotic germ cells, enabling timely meiotic entry in mice.

LOCATE uses long-read sequencing to detect transposon insertions, outperforming existing tools and revealing new insights into transposon insertion hotspots and mechanisms.

This study identifies how Toxoplasma gondii uses GRA effectors to manipulate host signaling and chromatin accessibility, promoting macrophage migration and parasite dissemination.

The paper identifies transcriptomic and genomic changes in the aging human brain using single-nucleus RNA-sequencing and single-cell whole-genome sequencing, revealing age-related gene expression patterns and somatic mutation dynamics.

The paper shows that A-MYB activates TCFL5, which is essential for meiosis and spermiogenesis in placental mammals, and its loss causes sterility.

This study identifies a conserved piRNA locus, pi6, essential for male mouse fertility and embryo viability by regulating sperm function through mRNA cleavage.

The paper identifies a network involving Cuff, TRF2, and CtBP that balances canonical and non-canonical piRNA precursor transcription in Drosophila.

The paper analyzes the piRNA response to retroviral invasion in koalas, finding that KoRV piRNAs are sense-biased and derived from unspliced transcripts, suggesting a conserved innate immune mechanism.