Heterologous expression of lyngbyatoxin biosynthetic genes in Aspergillus oryzae reveals transcriptional barriers but enables LtxC-mediated biotransformation
Sameera Jayasundara, Tahir Ali, Bisola Adeyemi, Bagyashri Krishnamoorthy, Calvin A. Henard, Kent Dean Chapman, Elizabeth Skellam
This study attempts to express cyanobacterial lyngbyatoxin biosynthetic genes in a fungal host, finding transcriptional barriers but functional downstream enzymes.
bioRxiv · May 16, 2026 · PreprintSynthetic Biology