Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor's Disease Susceptibility
C. Charles Gu, Andrea M. Matter, Amy Turner, Praful Aggarwal, Wei Yang, Xiao Song Sun, Steven C. Hunt, Cora Elizabeth Lewis, Donna K. Arnett, Blake D. Anson, Steve Kattman, Ulrich Broeckel
The paper assesses transcriptional variability in hiPSC-derived cardiomyocytes from donors with left ventricular hypertrophy, distinguishing technical from biological variability and identifying 'noise' and 'signal' genes.
bioRxiv · Apr 18, 2024 · PreprintGenetics