Wei Yang

Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia

This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.

SKIDA1 transiently sustains MLL::ENL-Expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming

This study identifies SKIDA1 as a gene promoting B-lineage priming in neonatal MLL::ENL-expressing hematopoietic progenitors, with implications for age-specific leukemogenesis.

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor's Disease Susceptibility

The paper assesses transcriptional variability in hiPSC-derived cardiomyocytes from donors with left ventricular hypertrophy, distinguishing technical from biological variability and identifying 'noise' and 'signal' genes.

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.

KDM6A knockout in human iPSCs alters the genome-wide histone methylation profile at active and poised enhancers, activating expression of ectoderm gene expression pathways.

This study shows that KDM6A knockout in human iPSCs changes histone methylation at enhancers, leading to increased ectoderm gene expression.

A secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

This study identifies ENDU-2, a secreted RNase in C. elegans, that maintains germline immortality by regulating mRNA abundance and preventing soma-specific gene misexpression in the germline.