Discovery of novel 1,4-dicarbonylthiosemicarbazides as DNA gyrase inhibitors for the treatment of MRSA infection
Gao Zhang, Jiaxin Liang, Gang Wen, Mingli Yao, Yuqing Jia, Bo Feng, Jishun Li, Zunsheng Han, Qingxin Liu, Tianlei Li, Wenxuan Zhang, Hongwei Jin, Jie Xia, Liang Peng, Song Wu
The paper discovers a new class of DNA gyrase inhibitors, 1,4-dicarbonylthiosemicarbazides, with potent activity against MRSA through design, synthesis, and biological evaluation.
European Journal of Medicinal Chemistry · Sep 27, 2024Peer-reviewedPharmacology & Toxicology