HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in brown adipocytes
Adrienne Guarnieri, Sarah Anthony, Pooja Acharya, Bo Yao Wen, Lindsey Lanzillotta, Rylie Gavin, Michael Tranter
This study identifies HuR-dependent regulation of RyR2 expression as critical for calcium-mediated thermogenesis in brown adipocytes, showing that HuR stabilizes RyR2 mRNA to enhance calcium cycling and heat production.
bioRxiv · Oct 22, 2024 · PreprintMolecular Biology