Sarah Anthony

This study shows WISP1 drives a unique proliferative and immune-modulatory myofibroblast state in cardiac fibroblasts, acting through a non-canonical P38 MAPK pathway.

This study identifies HuR-dependent regulation of RyR2 expression as critical for calcium-mediated thermogenesis in brown adipocytes, showing that HuR stabilizes RyR2 mRNA to enhance calcium cycling and heat production.

This study shows that inhibiting HuR reduces cardiac remodeling after ischemia-reperfusion injury by dampening inflammatory gene expression and immune response, but not initial infarct size.

This study shows that HuR-dependent Wisp1 expression is necessary for TGFβ-induced cardiac myofibroblast activity, as HuR inhibition reduces ECM remodeling and contractile functions.